Several species of Acanthamoeba, including A. culbertsoni, A. polyphaga, A. castellanii, A. astronyxis, A. hatchetti, A. rhysodes, A. divionensis. In order to define the mode by which amoebae recognize ECM components and process this recognition, we analyzed Acanthamoeba culbertsoni attachment. They have been implicated in human infections and disease, including Acanthamoeba culbertsoni, Acanthamoeba polyphaga, Acanthamoeba castellanii.

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Cutaneous leishmaniasis in Ethiopia: Echinococcus multilocularis metacestode metabolites contain a cysteine protease that digests eotaxin, a CC pro-inflammatory chemokine.

Table 2 Elicitation of footpad swelling with A. This supposition is consistent with the observation that A. Two distinct factors are required for induction of T-cell growth.

Activation of complement by Naegleria. Britten V, Hudson L. This protein is a homotrimeric type II acanthanoeba protein which has a C-terminal region outside the cell and an extracellular region that has homology to the corresponding region of members of the TNF family.

Acanthamoeba – Wikipedia

A hallmark culbertsnoi GAE is the formation of granulomas around the amoebae. Are the amoebae being credited to an ‘inside job’ done by the host immune response?


Acanthamoeba also has served as a model to study the evolution of certain G-proteins. BV-2 cells maintained in Neurobasal-A medium supplemented with A. Infect Immun ;30 1: The protein concentration of the conditioned medium was determined by the Bradford method 7.

Gel zymography of medium in which A. In vitro approaches to the mechanism of cell-mediated immune reactions.

Cell lysates were subjected to SDS-polyacrylamide gel electrophoresis and Western immunoblotting. Alternatively, exposure of BV-2 cells to Acanthamoeba spp. Progressive loss of H-2 antigens with concomitant increase of cell-surface antigen s determined by Moloney leukemia virus in cultured murine lymphomas.

Pathogen & Environment

acanthxmoeba A post mortem biopsy reveals severe oedema and hemorrhagic necrosis. Collectively, the results suggest that apoptosis induced by soluble factors in A. Furthermore, the capacity to induce apoptosis of microglia-like cells may articulate a mode by which A. Mitogenicity of Entamoeba histolytica extracts for human peripheral T lymphocytes.

Phase contrast micrograph of an Acanthamoeba polyphaga cyst. Table 4 Blastogenic response stimulation index of the splenocytes treated with LPS in mice infected with A. Infect Immun ;55 5: Primary neonatal rat microglia pMG culbrtsoni isolated from postnatal day 3 or 5 rat brains.


Several species of bacteria which can cause human disease are also able to infect and replicate within Acanthamoeba species.

Pathogen & Environment | Acanthamoeba | Parasites | CDC

Inhibition of in vitro lymphocyte blastogenesis by inhibitor produced by cultured human lymphoblasts. Enzyme immunoassays in diagnostic medicine. Korean J Parasitol Search. J Electron micrograph of a BV-2 cell maintained in medium supplemented with A. The blastogenic responses of splenocytes treated with concanavalin A were declined significantly in the experimental group as compared with the control group, but the blastogenic responses of splenocytes treated with polyinosinic acid were not different from the control group.

In the present study, it is demonstrated that A. Ferrante A, Thong YH. Bull World Health Organ ;53 1: