Part, Category. Description, 4-bit Shift Register. Company, ETC. Datasheet, Download datasheet. Quote. Find where to buy. Quote. # Store at. °C. 5-Formylcytosine (5-fC) (D5D4K) Rabbit mAb . as recommended in the antibody product datasheet) in 10 ml primary antibody. Datasheet PDF Download – 4-Bit Shift Register, data sheet.
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TET protein-mediated cytosine hydroxymethylation was initially demonstrated in mouse brain and embryonic stem cells 5, 8.
Please let us know! Methylation of DNA at cytosine residues is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting, and mammalian development 1,2. The upper panel shows the antibody only binding to the DNA fragment containing 5-fC, while the lower panel shows the membrane stained with methylene blue. Furthermore, there is an inverse correlation between levels of 5-hmC and histone H3K9 and H3K27 trimethylation, suggesting a role for 5-hmC in gene activation Additionally, TET proteins can further oxidize 5-hmC to form 5-formylcytosine 5-fC and 5-carboxylcytosine 5-caCboth of which are excised by thymine-DNA glycosylase TDGeffectively linking cytosine oxidation to the base excision repair pathway and supporting active cytosine demethylation 6,7.
74178 Datasheet PDF
Find your product Go. Please change your password to something memorable and daatsheet upon logging in. While 5-fC and 5-caC appear to be short-lived intermediate species, there is mounting evidence showing that 5-hmC is a distinct epigenetic mark with various unique functions 10, The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
(Datasheet) pdf – 4-Bit Shift Register (1-page)
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If so we’d love to hear about it. Datasheet Datasheet CST Have you published research involving the use of our products? As shown in the graph, the antibody only binds to the oligo containing 5-fC. Login Create new account. Background Methylation of DNA at cytosine residues is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting, and mammalian development 1,2.
Application References Have you published research involving the use of our products? Enter your username and we will send datasyeet a link to reset your password if an associated user is found. You will receive an e-mail from us containing your new password in the coming minutes.
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Lower amounts of 5-hmC have been reported in various cancers including myeloid leukemia and melanoma 13, Login No need to login datsheet view prices! Product has been added to your cart. The supporting documents available for this product can be downloaded below. Since then this modification has been discovered in many tissues, with the highest levels found in the brain 9.
Many cells and tissues contain very fatasheet endogenous levels of 5-fC that may fall below the detection limits of this antibody. Therefore webshop accounts that were only used to view prices have been deleted. We are committed to providing you with a productive and privacy-friendly website.
The global level of 5-hmC increases during brain development, and 5-hmC is enriched at promoter regions and poised enhancers. No need to login to view prices! Your credentials are incorrect or you are trying to login with a non-existing webshop account. The same sequence of a base pair DNA fragment was generated by PCR using exclusively unmodified cytosine, 5-methylcytosine 5-mC5-hydroxymethylcytosine 5-hmC74187 5-caCor 5-formylcytosine 5-fC. The modified base itself is stable in vivo and datasheef with various readers including MeCP2 11, You will receive an e-mail containing a link to start the recovery procedure within minutes.
This product is intended for research purposes only.