Antioxidant and antiradical activities of L-carnitine. Gülçin, I. Life Sciences 78(8): L-carnitine plays an important regulatory role in the. Antioxidant and antiradical activities of l-carnitine. I˙lhami Gьlзin *. Atatьrk University, Faculty of Arts and Sciences, Department of Chemistry, TR Erzurum-. L-carnitine plays an important regulatory role in the mitochondrial transport of long-chain free fatty acids. In this study, the antioxidant activity of L-carnitine was .

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The absorbance value of the reaction mixture l-carnifine recorded at nm. Biochimica and Biophysica Acta— Absorbnce nm that their main action as peroxidation protector may be related to its iron binding capacity. In vitroantioxidant and scavenging activities of Hibiscus rosa sinensis crude extract Faten R. Reviews on mechanisms of in vitro antioxidant activity of.

Activifies are continuously produced during normal physiologic events and they can easily initiate antiradiacl peroxidation of membrane lipids, leading to the accumulation of lipid peroxides. A solution of H2O2 40 mM was prepared in phosphate buffer pH 7. Journal of Ethnopharmacology 90, — Thus, the reduction in lipid peroxidation in the present study might be due to the ironchelating property of l-carnitine Arduini, Excessive formation of free radicals accelerates the oxidation of lipids in foods and decreases food quality and consumer acceptance Min, Food Chemistry 87, — The peroxide level was determined by reading the absorbance at nm in a spectrophotometer II, Bio-Crom GmbH, Zurich, Switzerland after reaction with FeCl2 and thiocyanate at intervals during incubation.


Marcel Deckker, New York, pp. It was reported that the compounds with structures containing two or more of the following functional groups: Total antioxidant activity of l-carnitine, a-tocopherol and trolox was determined by the 0 5 10 15 20 25 30 35 40 Time Hour Fig.

Antioxidant and antiradical activities of L-carnitine. – Semantic Scholar

Also, l-carnitine has a protective effect on the activity of mitochondrial enzyme succinate dehydrogenase as well as the activity of the antioxidant enzymes, catalase and superoxide dismutase against 3-NPA-induced neurotoxicity Binienda and Ali, International Journal Of Food Properties: Determination of in vitro Oktay, M. The reaction scheme between DPPH and l-cagnitine. Lebensmittel Wissenchaft und-Technologie 36, — Food and Chemical Toxicology 26, — An abstraction of a hydrogen atom from C-2 may be occurred easily.

Respiratory Physiology— Metal chelating capacity was significant since it reduced the concentration of the catalysing transition metal in lipid peroxidation.

Biochemica and Biophysica Acta23 — The data obtained from Fig. As hypothesized Shug et al. The antioxidant properties of the L-carnitine were evaluated by using different antioxidant assays such as antiradicaal, 1-diphenylpicryl-hydrazyl free radical DPPH.

The reducing power of lcarnitine was determined by the method of Oyaizu Grice, ; Moure et al.

To our knowledge, DPPH radical scavenging mechanism of lcarnitine has not been reported so far. All other chemicals used were in analytical grade and obtained from either Sigma-Aldrich or Merck.

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Statistical analysis All data on total antioxidant activity are the average of duplicate analyses. Superoxide anion plays an important role in the formation of other ROS such as hydrogen peroxide, hydroxyl radical, and singlet oxygen, which induce oxidative damage in lipids, proteins, and DNA Pietta, Role of l -carnitine in sports performance: Antioxidant, free radical scavenging activities and total.


It can also reduce certain iron complex such as cytochrome c. The antioxidant activity of lcarnitine and standards was determined according to the ferric thiocyanate method mitsuda et al.

Free Radical Biology and Medicine 20, 35 — Journal of agricultural and food chemistry 49 6: American Journal of Clinical Nutrition 53, — The inhibition of superoxide radical generation results of l-carnitine and standards were found ajtioxidant statistically. The metal chelating effects of l-carnitine were concentration-dependent.

Antioxidant and antiradical activities of l-carnitine pdf

In this study, we evaluated the possible antioxidant effects of l-carnitine in different in vitro antioxidant assays including 1, 1-diphenylpicryl-hydrazyl free radical scavenging, total antioxidant activity by ferric thiocyanate method, reducing power, antioxidanf anion radical scavenging, hydrogen peroxide scavenging and metal chelating activities.

Annals of Neurology 24, — Total phenolic content, antiradical, antioxidant and antimicrobial activities of Rhododendron honeys.

As a dietary supplement to improve athletic performance, carn has been studied for its potential to enhance. P values ferric thiocyanate method in the linoleic acid system.