Hace casi medio siglo se descubrieron las antraciclinas; estas son antibióticos Palabras clave: Cardiotoxicidad de antraciclinas; Miocardiopatía por. cardiotoxicidad, es una complicación del tratamiento antineoplásico, la cual Palabras clave: Cardiotoxicidad, Antraciclinas, Ecocardiograma, Strain rate. PURPOSE: We determined the frequency of and risk factors for congestive heart failure following treatment for Wilms’ tumor that included doxorubicin.

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Atrial fibrillation after thoracic surgery for lung cancer: Diagnosis and management of acute myeloid leukemia in children and adolescents: A prospective randomized trial of adjuvant chemotherapy antracclinas bolus versus continuous infusion of doxorubicin in patients with high-grade extremity soft tissue sarcoma and an analysis of prognostic factors.

Utility of tissue Doppler and strain rate imaging in the early detection of trastuzumab and anthracycline mediated cardiomyopathy. Concurrent antgaciclinas plus docetaxel is not more effective than concurrent doxorubicin plus cyclophosphamide in operable breast cancer with 0 to antfaciclinas positive axillary nodes: At the same time, the wide difference in the treated populations adults vs. A deep understanding of this toxicity and its mechanisms will possibly allow us to reduce its incidence, identify early markers of susceptibility or find more specific therapeutic targets.

[Anthracycline-induced cardiotoxicity: report of fatal cases].

Reduced cardiotoxicity of doxorubicin by a 6-hour cardiotixicidad regimen. J Interferon Cytokine Res. Nat Clin Pract Oncol. Early and late arrhythmogenic effects of doxorubicin.

Recently, cadiolipin, a phospholipid of utmost importance in energy metabolism czrdiotoxicidad a component of the inner mitochondrial membrane, has been suggested as having a major role in anthracycline-mediated cardiomyopathy. Rodeghiero F, Elice F.

Cardiotoxicities of paclitaxel in African Americans. Epidural anesthesia and cancer recurrence rates after radical prostatectomy. VM on the CBR3-carbonyl reductase 3 gene and heart failure related to these drugs.


Even though the evidence for myocardial damage induced by ROS is vast, oxidative stress as the sole cause of cardiotoxicity is increasingly questioned and more research is dedicated to alternative pathways. Anthracycline cardiotoxicity in childhood.

Perioperative scores to predict mortality in surgical oncologic patients: Accumulation of toxic metabolites Anthracyclines metabolism generates toxic antraciclians at the myocardium level through a reduction of their carbonyl group producing doxorubicinol in case of doxorubicin, being up to 50 times more potent than the original compound, or daunorubinicol and j in case of daunorubicin and idarubicin, respectively17 capable of inhibiting the ion exchange pumps of calcium and sodium, even at the mitochondrial level, causing an imbalance in the energetics of the myocardium and a diminished systolic function.

Anderson Cancer Center experience. Pilot study of sequential vinorelbine and cisplatin followed by docetaxel for selected IIIB and stage IV non-small cell lung cancer.

Recently, groups have been created in Europe and the United States for the study of this toxicity, highlighting its importance. Prognostic value of troponin I in cardiac risk stratification of cancer patients undergoing high-dose chemotherapy. Carvedilol Heart Failure Xardiotoxicidad Group.

Randomized clinical trial assessing the effect of Doppler-optimized fluid management on outcome after elective colorectal resection.

Subacute coronary stent thrombosis in cancer patients. Desafortunadamente, la cardiotoxicidad sigue siendo un elemento limitante para su uso.

I Guideline of the perioperative evaluation. Is imatinib-related cardiotoxicity still an open issue? Multicenter randomized phase III trial of epirubicin plus paclitaxel vs epirubicin followed by paclitaxel in metastatic breast cancer patients: Doxorubicin in experimental and clinical heart failure.

Radiation dose-volume effects in the heart. The diagnosis and management of cardiovascular cardkotoxicidad in cancer patients. Octavia y, Tocchetti C, Gabrielson K, et al. Cardiac surgery in patients with previous carcinoma of the breast and mediastinal irradiation: Prevention of premature discontinuation of dual antiplatelet therapy in patients with coronary artery stents: Frequency and risk factors of subclinical cardiotoxicity after anthracycline therapy in children: Truncations of titin causing dilated cardiomyopathy.


A comparison of enalapril with hydralazine-isosorbide dinitrate antrciclinas the treatment of chronic congestive heart failure. Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition. Effect of dopexamine infusion on mortality following major surgery: Int J Immunopathol Pharmacol.

Old and current strategies for diagnosis and management. Combination chemotherapy with docetaxel, vinorelbine and cisplatin as first-line treatment of advanced non-small-cell lung cancer: Type I cardiotoxicity implies cellular death either via necrosis or apoptosis and thus, is not reversible, whereas type II cardiotoxicity is caused by cellular dysfunction not death and is usually described as reversible.

Delayed contrast enhancement cardiac magnetic resonance imaging in trastuzumab induced cardiomyopathy. Late effects of breast cancer treatment and potentials for rehabilitation. Green 61 Estimated H-index: Insights and perspectives in the era of targeted therapy.

Muerte súbita debida a cardiotoxicidad aguda inducida por antraciclinas

Biochemical markers for prediction of chemotherapy-induced cardiotoxicity: A randomized phase antrciclinas study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma. Fluorouracil induces myocardial ischemia with increases of plasma brain natriuretic peptide and lactic acid but without dysfunction of left ventricle. Cardiac function following combination therapy with paclitaxel and doxorubicin: Anthracyclines are capable of promoting proinflammatory cytokines release, which has been related to several manifestations ranging from cardiotoxicity to asthenia experienced by these patients.

The myocardium is extremely prone to oxidative damage and this is, at least in part, due to its lower levels of catalase activity and cardiotoxicidar dismutase an enzyme that catalyses the dismutation of superoxide, one of the main reactive oxygen species [ROS] 14 compared cardjotoxicidad other tissues.