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Choose Selective Histone Methyltransferase Inhibitors. Bio Calculators Molarity Calculator Molarity Calculator Calculate the mass, volume or concentration required for a solution.
MI has very favorable drug-like properties, including metabolic stability and pharmacokinetic profile in mice. The cell growth inhibitory effect of MI is time-dependent, with a pronounced effect achieved after days of treatment.
To calculate molar mass of a chemical compound, please enter its chemical formula and click ‘Calculate’.
MI is also very effective in inducing differentiation of MLL leukemia cells and substantially increases expression of CD11b, a myeloid differentiation marker. The Selleck dilution calculator is based on the following equation:. Histone Methyltransferase Signaling Pathway Map. References  Borkin D, et al. Molecular mass molecular weight is the mass of one brc of a substance and is expressed in the unified atomic mass units u.
This is normal and is due to slight batch-to-batch variations. In vivo MI has vatasheet favorable drug-like properties, including metabolic stability and pharmacokinetic profile in mice. This equation is commonly abbreviated as: MI could substantially improve survival of MLL leukemic mice and does not impair normal hematopoiesis in vivo .
It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines GI50 at nM nM rangebut only a minimal effect in human leukemia cell lines without MLL translocations. Menin-MLL interaction  Cell-free assay. Prolonged treatment 38 days with MI induces no toxicity in mice as reflected by no alterations in the body weight and no morphological changes in liver and kidney tissues.
For cell differentiation studies, leukemia cells are treated with menin-MLL inhibitors for 7 days, then harvested, washed and incubated with Pacific Blue rat anti-mouse CD11b antibody before being analyzed by flow cytometry. Calculate the dilution required to prepare a stock solution.
The Selleck molarity calculator is based on the following equation:. Media is changed at datasheef 4, viable cell numbers are restored to the original concentration and compounds are re-supplied. Answers to questions you may have can be found in the inhibitor handling instructions. For viability assays, leukemia cells are plated at relevant concentrations and treated with compounds or 0.
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Topics datxsheet how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments. Molecular Weight Calculator Molecular Weight Calculator Enter the chemical formula of a compound to calculate its molar mass and elemental composition: Dilution Calculator Dilution Calculator Calculate the dilution required to prepare a stock solution. Calculate the mass, volume or concentration required for a solution.
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These effects are accompanied by reduced c-kit CD expression, a marker associated with leukemia stem cells LSCs. Treatment with sub-micromolar concentrations of MI also leads to markedly reduced expression of Hoxa9 and Meis1, downstream targets of MLL datasyeet proteins substantially upregulated in MLL leukemias . The Selleck molarity calculator is based on the following equation: It blocks hematologic tumors in vivo and reduces MLL leukemia tumor burden.
Serial Dilutions Concertration start: The Selleck dilution calculator is based on the following equation: Tech Support Answers to questions you may have can be found ncr the inhibitor handling instructions.
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