British anti-Lewisite (BAL; dimercaprol; 2,3-dimercaptopropanol) has been in use in the medical community for over 60 years. It is most commonly used as a. Dimercaprol is the drug of choice for treatment of acute arsenic, inorganic or elemental mercury, gold, and inorganic lead (in combination with EDTA) poisoning. The development of BAL must first start with its nemesis: Lewisite. Lewisite is a combination of acetylene and arsenic trichloride (figure 1) and has also been.

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Human and Experimental Toxicology Keep Exploring Britannica Television. The Editors of Encyclopaedia Britannica.

British anti-Lewisite (dimercaprol): an amazing history.

Archived PDF from the original on 23 April Plans for the possible production ofpounds per year were developed Waters and Stock We welcome suggested improvements to any of our articles. Dimercaprolalso called British anti-lewisite BALdrug that was originally developed to combat the effects of the blister gas lewisitewhich was used in chemical warfare.

BAL is not generally recommended for use today because more efficient and safer chelators for oral or parenteral administration have been developed Andersen ; Nritish et al ; Archer Retrieved from ” https: Internet URLs are the best. Dimercaprol was first made during World War II. British anti-Lewisite was developed in as an antidote to lewisite, an arsenic-based chemical warfare agent.


Nonetheless, because it can have serious adverse effectsresearchers have also pursued development of less toxic lrwisite. Chronicle of a Twentieth Century Medical Triumph.

Archived PDF from the original on 13 December Automobile, a usually four-wheeled vehicle designed primarily for passenger transportation and commonly…. Views Read Edit View history.

Help us improve this article! Dimercaprol is itself toxic, with a narrow therapeutic range and a tendency to concentrate arsenic in some organs.

Other drawbacks include the need to administer it by painful intramuscular injection. This drug is not indicated in patients with iron, cadmium, selenium, silver, or uranium poisoning.

Dimercaprol | drug |

Dimercaprol is more effective if its use is begun within two hours after ingestion of the toxic metal. Television TVthe electronic delivery of moving images and sound from a source to a receiver.

Thank you for your feedback. Dimercaprol has been found to form stable chelates in vivo with many other metals including inorganic mercuryantimonybismuthcadmiumchromiumcobaltgoldand nickel.

More About Dimercaprol 1 reference found in Britannica articles Assorted References arsenic poisoning In arsenic poisoning. InPorter found a 7-fold increase in copper excretion in 2 patients with Wilson disease and some decrease in neurologic signs after treatment with BAL Porter Retrieved 22 April British anti-Lewisite is occasionally used for both acute heavy metal intoxication and Wilson disease.

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Arsenic poisoning Dimercaprol Succimer.

British anti-Lewisite (dimercaprol): an amazing history.

Goals and duration of treatment. It was also considered effective in cases of intoxication with bismuth, copper, and nickel Deichmann and Gerarde Dimercaprol also enhances the toxicity of selenium and telluriumso it is not to be used to remove these elements from the body.

BAL s use as the primary treatment for Wilson disease was short-lived because Walshe, inshowed britksh value of the less toxic chelating agent, penicillamine Walshe Lorincz beitish the University of Michigan has no relevant financial relationships to disclose. Nevertheless, BAL may still have some therapeutic value in patients who do not respond well to more modern agents Scheinberg and Sternlieb