Corneal Collagen Cross-Linking with Riboflavin (also abbreviated as C3R) is a non-invasive corneal treatment shown to slow the progression of keratoconus. What is the treatment for Keratoconus? 1. Use of Contact Lenses (Corneal Collagen Crossling Procedure) . (Information & Appointments for C3R). Fax: Strengthens the cornea with less evasive procedures– The solution will I have done a c3r procedure in my left eye and after c3r my number is.

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This simple, procedurs procedure begins with the application of riboflavin vitamin B2 drops on the cornea which are then activated with a mild UV Ultraviolet light.

Similar to the Dresden study, its interpretation and application to a wider set of patients is limited by a poorly defined patient population. CXL of the cornea has been shown to have an anti-edematous effect in the cornea. Investigation also proved that the treated corneas contained higher molecular weight polymers of collagen due to fibril crosslinking. One does need to be aware of proceduee deterioration in vision.

Likewise, the best candidate for this therapy c3t an individual with a progressive ectatic disease of the cornea. Q When can I start driving? In a recent retrospective study of eyes of patients c3t stage keratoconus, 8. No lens opacities cataracts have been attributed to this treatment in European trials. More and more researchers are realizing epi-on technique is safer and provides the same results. If the treatment with CXL stops or slows the progression of keratoconus, while other methods can reshape the cornea, a logical solution would be proedure combine the two treatment methods in order to synergize their effects.


The treatment is performed in our procedkre theatre under complete sterile conditions. The transepithelial approach was only to combat the discomfort that lasts for a day or so, but with the flipside that the C3R procedure effectiveness was reduced, healing was uneven. You can contact Dr. Riboflavin-UVA treatment in the management of edema and nonhealing ulcers of the cornea. In all instances the patient is first given anesthetic drops.

Q Would I be required to come to Mumbai for any future check ups?

Corneal Collagen Cross-Linking

Q After the C3-R treamtent will my vision be perfect and I can avoid the glasses? In this combined method, a pre-treatment with an alternative method would significantly reshape the cornea by flattening and regularizing corneal shape, which would be followed by CXL to stabilize the cornea. In a prospective study, Kanellpoulos included a total of eyes with keratoconus. Therefore, for clinical use, a uniformly emitting irradiance source is required, and must be continuously evaluated.

The main aim of this treatment is to arrest progression of keratoconus, and thereby prevent further deterioration in vision and the need for corneal transplantation.

As was said in reply to others with similar situations, if your vision is blurred after Crosslinking I would suggest seeing your c3d. A lid speculum is placed. If they are from out of Procsdure, then one plans accordingly. Keratocyte apoptosis in the anterior segment of the corneal stroma all the way down to a depth of about microns has been described and a demarcation line between the treated and untreated cornea has been clearly shown.

A treatment in the rabbit. The saturation of the cornea with riboflavin and its presence in the anterior chamber is monitored closely by slitlamp inspection prior to treatment.


For each study listed below, the definition of progression is emphasized due to its importance in our understanding of the resultant data. The first in vivo controlled clinical study by Wollensak et al.

Benefits of Corneal Collagen Crosslinking with Riboflavin

The observational evidence for the role of corneal crosslinking has been strong. A new world of natural vision could be waiting for you. Pls tell me what kind of infections possible after c3r surgery and when will I be get proper vision back. How long prpcedure it take for me to join office from the time of operation? CXL without removal of the epithelium A cross-linking procedure without epithelial removal would likely be less painful than one with the large diameter epithelial removal proceudre above and would be ideal if it efficiently stabilized keratectasia.

This method is preferred by Dr Anand Shroff.

C3r Procedure, Treatment and Cost

The interaction of Riboflavin and UV light causes the links within the cornea to re-bond and strengthen over proceudre. In most cases, the contact lens is removed on the third day after treatment.

This time point of crossover was changed at the request of FDA. Next, drops of riboflavin are administered, followed by UV exposure.