Lobular carcinoma in situ (LCIS) is an area (or areas) of abnormal cell growth that increases a person’s risk of developing invasive breast. Lobular carcinoma in situ (LCIS) is an incidental microscopic finding with characteristic cellular morphology and multifocal tissue patterns. The condition is a. Lobular carcinoma in situ (LCIS) represents the next step up from atypical lobular hyperplasia (ALH) along the malignant spectrum of lobular breast carcinoma.

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Lobular neoplasia is considered pre-cancerous, and LCIS is an indicator marker for increased risk of developing invasive breast cancer in women. This may be followed by delayed breast reconstruction.

LCIS may be treated with close clinical follow-up frequent scheduled checkups and mammographic screeningtamoxifen or related hormone controlling drugs to reduce the risk of developing cancer, or, if patients and providers would like a less conservative option,bilateral prophylactic mastectomy. The exception may be carcinoja LCIS which is a more aggressive subtype which may be associated with mammographically-detectable calcifications 2.

Warthin’s tumor Thymoma Bartholin gland carcinoma. LCIS involves terminal duct lobular unit TDLU filling and expanding acini Proliferation of monomorphic, loosely cohesive cells that are evenly spaced “marbles in a bag”slightly larger than normal, with indistinct cell borders and pale cytoplasm, have uniform small nuclei, evenly distributed chromatin and inconspicuous nucleoli Two types of cells are described: In addition, in situ and invasive lesions exhibit loss of cellular adhesion, considered a characteristic histologic feature, due to the fact that e-cadherin expression is lost transmembrane protein involved in epithelial cell adhesion.

LCIS is an uncommon condition in which abnormal cells form in the lobules or milk glands in the breast.

Lobular Carcinoma In-Situ and Invasive Lobular Carcinoma

LCIS occurs predominantly in premenopausal women with a mean age of 45 years old, approximately years younger than the mean age when invasive breast carcinoma occurs. American Society of Clinical Oncology. Atypical lobular hyperplasia as a unilateral predictor of breast cancer risk: Women who have developed histologically flagrant examples of lobular neoplasia like Carcinlma are about 9 times more likely than the average women to develop breast cancer.


This is cacinoma true if the LCIS is described as pleomorphic or if it has lbulillar areas of dead cellsin which case it might be more likely to grow quickly. If LCIS is detected in a breast biopsy, it doesn’t mean that you have cancer. One also looks for any deviation from the classical pattern of lobular neoplasia.

Which of the following is false?

Click here for information on linking to our lpbulillar or using our content or images. Certainly higher than one might expect proportional to lesion size.

One of the ways in which specialists establish these different LCIS grades is the percentage of time that LCIS subsequently needs to be upstaged following the initial diagnosis. Emily S Reisenbichler, M. LCIS is often found concurrently with foci of invasive carcinoma and multiple studies have shown, using genetic sequencing techniques, that synchronous LCIS and ILC share clonal cell populations, or originate from the same line of mutated cells.

Once doctors detect LCIS they will likely advise a number of additional tests, including: This content does not have an English version. That being said, the historical approach of radical mastectomy surgical removal of entire breast and axillary lymph nodes has been substituted by more conservative approaches.

However, women with the more subtle histological lobular subtypes atypical lobular neoplasia are perhaps 4 times more likely than the average women in terms of risk of developing breast cancer.

While older studies have shown that the increased risk is equal for both breasts, a more recent study suggests that the ipsilateral same side breast may be at greater risk. This would seem to be a bad thing, but in fact, with invasive breast cancer local recurrence is a secondary concern; the main worry is metastasis to the lymph nodes and beyond. In these scenarios, pathologists may employ immunohistochemical testing to differentiate between entities.


Unlike invasive lobular carcinomathey leave the basement membrane intact. Lobular carcinoma in situ. Frigerioand J. Routine mammograms showing suspicious radiologic findings warrant a core needle biopsy in the abnormal area seen radiologically, and may or may not show lobular neoplasia histologically. The risk of developing breast cancer for women in general is thought to be 12 percent.

Treatment of Lobular Carcinoma in Situ (LCIS)

The lobes are further divided into smaller lobules that produce milk for breast-feeding. Edit article Share article View revision history. The risk of breast cancer in women diagnosed with LCIS is thought to be approximately 20 percent.

Once lobulillat, the lobules are really the milk producing glands, which present milk to the ducts, which in turn carry it to the nipple. Articles Cases Courses Quiz. National Comprehensive Cancer Network. What are the symptoms of lobular carcinoma in situ? About Blog Go ad-free.

Invasive Lobular Carcinoma and Lobular Carcinoma In-Situ – Moose and Doc

Churchill Livingstone Elsevier; Make an appointment with your doctor if you notice a change in your breasts, such as a lump, an area of puckered or otherwise unusual skin, a thickened region under the skin, or nipple discharge.

Request an Appointment at Mayo Clinic. What is more important is the aggressive nuclear features in the biopsy specimenand this can usually be accurately cagcinoma with a core biopsy lbulillar. Board review question 3. Presence of lobular carcinoma in situ does not increase local recurrence in patients treated with breast-conserving therapy.