Correspondence from The New England Journal of Medicine — Cellulitis. To the Editor: In their article on the Prophylactic Antibiotics for the Treatment of Cellulitis at Home I (PATCH I) trial, Thomas et al. (May 2 issue)1 report that the. In a recent retrospective study of patients who were hospitalized with presumed cellulitis, dermatologists concluded that roughly 30% of.

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Penicillin to prevent recurrent leg cellulitis.

Treat tinea pedis or candida infection with topical terbenifine or miconazole respectively. The median time to a first recurrence of cellulitis was days in the penicillin group and days in the placebo group. Prophalactic antibiotics for the vellulitis of cellulitis erysipelas of the leg: Bilateral cellulitis is uncommon. Refer for specialist opinion if severe infection Is it cellulitis? Baseline characteristics were similar in the two groups. Is it chronic changes of venous stasis and chronic ulceration?


Penecillin to prevent leg cellulitis NEJM ; Amiodarone and drugs which prolong the QT interval can interact with many antibiotics.

Leg Ulcers and recurrent cellulitis

We compared prophylactic low-dose penicillin with placebo for the prevention of recurrent cellulitis. Are they suitable for compression?

Doses are oral and for adults unless otherwise stated. Please refer to our Drug Interactions Table for further information. Antibiotics do not improve healing unless active infection.

The primary outcome was the time to a first recurrence. Review antibiotics after culture results.

A total of patients were recruited. Many antibiotics increase the risk of bleeding with anticoagulants.

Penicillin to prevent recurrent leg cellulitis.

Statins can interact with some antibiotics and increase the risk of rhabdomyolysis. In patients with recurrent cellulitis of the leg, penicillin was effective in preventing subsequent attacks during prophylaxis, but the protective effect diminished progressively once drug therapy was stopped.

Nejmm to main content.

Comment in N Engl J Med. Because the risk of recurrence was not constant over the 3-year period, the primary hypothesis was tested during prophylaxis only.


Leg Ulcers and recurrent cellulitis –

Leg Ulcers and recurrent cellulitis. Overall, participants in the penicillin group had fewer repeat episodes than those in the placebo group vs. We conducted a double-blind, randomized, controlled trial involving patients with two or more episodes of cellulitis of the leg who were recruited in 28 hospitals in the United Kingdom and Ireland.

Randomization was performed according to a computer-generated code, and study medications penicillin [ mg twice a day] or placebo for 12 months were dispensed by a central pharmacy. N Engl J Med. Participants were followed for up to 3 years.

Colonisation is likely in leg ulcers. Comments from Expert Advisory Committee Antibiotics do not improve healing unless active infection. Cellulitis of the leg is a common bacterial infection of the skin and underlying tissue.