Classics in Total Synthesis. By K.C. Nicolaou and E. J. Sorensen. Article (PDF Available) in Molecules 3(2) · February with 2, Reads. This book is essential for any synthetic organic chemist.[ ]. K. C. NICOLAOU, E. J. SORENSEN. CLASSICS IN. TOTAL. Page 2. Classics in Total Synthesis K. C. Nicolaou and. – E. J. Sorensen. VCH.

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Chen received his A. Important reactions are additionally deepened.

Shipping Add to Cart. Some small sections describe problems associated with structure elucidation, which then led to revision of the supposed structure in the context of the total synthesis e.

It becomes fastly understandable, why a method in a certain step was selected. Chen received his A. Using his didactically skillful approach, K. This clearly demonstrates the increasing stnthesis, but also industrial, importance of complex syntheses of natural products.

Book Review: Classics in Total Synthesis – K. C. Nicolaou, E. J. Sorensen

Nicolaou has made outstanding contributions in his research field. Nicolaou compiles and contrasts the important synthetic methods that lead to a complex molecule with valuable properties. That Woodward used “State of the Art” – techniques purposefully and with an ingenious planning skill, is appreciated in this book. The main author Nicolaou is a top-notch US chemist, who is now regarded as the world’s leading synthetic chemist. This alone is one of the great strengths of the book, and provides every synthetic chemist with an excellent pool for the classids of his or her own synthetic problems.

Didactically skillful approach, reflecting the world-wide standard way of teaching organic synthesis introduction, retrosynthetic analysis, synthesis. Most synthesis of natural products require a special cladsics The layout of this book has only been slightly changed compared classcis previous volumes. Retaining his excellent, proven approach, world-famous chemist and passionate teacher K.


He explains all the key steps of the synthetic pathway, highlighting the major developments in blue-boxed sections and contrasting these to other synthetic methods. Copious references to reviews and the original literature make this book a gold mine of information for every organic chemist in industry and academia.

This series can therefore already be justifiably called a classic in itself. Nicolaou – Winner of the Nemitsas Prize in Chemistry This book is a must for every synthetic chemist. He currently is a post-doctoral fellow in Professor Nicolaou’s laboratory.

Further Targets, Strategies, Methods. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. The selected examples cover a large range of methods and very important natural products. Nicolaou with various co-authors. Graduate students classic researchers alike will find this book a gold mine of useful information essential for their daily work.

Important formulas are, in addition, depicted in the margin, next to the passage where they are mentioned in the text. His impact on chemistry, biology and medicine flows from his research works in chemical synthesis and chemical biology described in numerous publications and patens.

His impact on chemistry flows from his works in chemical synthesis and chemical biology described in over publications and 55 patents.

Classics in Total Synthesis: Targets, Strategies, Methods

Special emphasis is placed on the skillful use of graphics and schemes: With didactic skill and clarity, K. Nicolaou compiles here the important strategies and tools employed to construct complex molecules. All the key steps of the synthetic pathway are explained, with major developments highlighted in blue boxes. The review of asymmetric halogenation reactions Chapter The authors carefully explain each synthetic step and give hints on alternative methods and potential pitfalls.

To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. But of that multitude, only a few books cclassics been as outstanding in recent classiccs as the series Classics in Total Synthesis, written by K.


For easy reference, key intermediates are also shown in the margins. This book is a nicolao for every synthetic chemist.

Similar to its predecessors and completing the trilogy, this textbook analyzes the syntheses in a didactic manner, with several chapters including mini-reviews of key methodologies, and an emphasis on the history, mechanism, scope, and generality of the reactions.

This book will certainly contribute its share to ensuring that these syntheses will be used as outstanding models for teaching and research purposes, even 20 or more years from now. The introductions to the chapters often feature insights into the biosynthesis of the natural product concerned e.

On the other hand, the great success of this series does support a continuation of the style in its present form. Nowadays, books that concentrate on the area of organic synthesis are numerous enough to fill whole inventories of libraries.

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Classics in Total Synthesis

Each chapter begins with background information about the discovery, structure elucidation, and biological significance of the target molecule s. With didactic skill and clarity, K. Such explanations, and possibly also descriptions of unsuccessful attempted routes, could give the reader an even more detailed insight into problems of reactivity or selectivity of a specific reagent or substrate. A particularly extensive account is given in Chapter 3, which describes an impressive 60 g totall synthesis of discodermolide by Novartis.

For a total of 42 syntheses of 25 challenging natural products he explains all the key steps of the synthetic pathway, highlighting the major developments in blue-boxed sections for easier understanding, and contrasting these to other synthetic methods.