El haloperidol durante dos meses reapareci la corea cual resolvi pidamente reinstaurar tratamiento. Request PDF on ResearchGate Chor de Sydenham chez . Sydenham se graduó de la Universidad de Oxford en y obtuvo el título de del láudano de opio y de la corteza del árbol de chinchona en el tratamiento de logros están el descubrimiento de la Corea de Sydenham, también conocida. eficacia de carbamazepina, haloperidol y acido valproico en el tratamiento de niños con corea de Sydenham: seguimiento clínico de 18 pacientes’ in DOAJ.

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Randomized double-blind study with prednisone in Sydenham’s chorea. Sptreptozyme values were increased in 10 patients Of the immunomodulatory therapies investigated, steroids have the strongest supporting evidence, but side effects are not uncommon. Age of patients ranged from 7 to 15 years. On the other hand, Bob and Bill W.

Brain human monoclonal autoantibody from Sydenham chorea targets dopaminergic neurons in transgenic mice and signals dopamine D2 receptor: Thus, other multicentric and comparative studies involving more patients are mandatory in order to answer the question of which drug is best for each particular child affected by SC.

Penicillin prophylaxis appears to reduce the likelihood of further cardiac complications and the recurrence rate of chorea. Examples of tragic cases in the past are Ernest Hemingway, whose corea de sydenham fisiopatologia also suffered five suicides including Hemingway himselfand Eugene ONeill with three suicides in his family.



The study group included 32 patients with SC that were referred to the Pediatric Neurology department of the University Hospital of Maracaibo, Venezuela during the period January 1 st.

The goal of this review was to critically analyze the available literature on the treatment of chorea in individuals with SC. Recurrence of Sydenham chorea: Coreea Paediatr Child Health.

Wydenham J Med ; Neuroimaging is usually unremarkable Our suggested approach to treatment is presented. A small comparison study randomized 18 SC patients to treatment with either carbamazepine, valproic acid, or haloperidol.

Five patients receiving carbamazepine showed improvement without side effects. Br Med J ; As shown in Table 2in addition to the choreic movements other clinical manifestations that were readily evident, included emotional instability, gait disturbances, motor agitation, abnormal reflexes, dysarthria, and generalized weakness.

Sedatives, dopaminergic receptor antagonists, and other drugs reduce the time of convalescence of the patients that harbor this disorder, with varying degrees of success. Concerns for this study include lack of placebo control arm, use of a non-validated rating scale, and failure of the blinded observer to perform the initial evaluation at the beginning of the protocol.


Three of the six patients treated with HP showed improvement following 5 days of treatment, two of these had treatment related side effects: A case report suggested that tetrabenazine administered to two patients with SC 25 twice a day or three times a dayis an effective chorea therapy in SC.

Solo tres de los pacientes que recibieron haloperidol mejoraron.

Treatment of Sydenham’s Chorea: A Review of the Current Evidence

Authors that have used VPA or sodium valproate in SC reported similar results as those obtained with HP, with less adverse effects, notwithstandingly 5,11, The remaining case failed to improve. How to cite this article. Thus, the condition may be misdiagnosed as an ailment of psychological origin.

Resurgence of acute rheumatic fever in the inter-mountain area of the United States. Patient xorea was based on the following criteria: Campen R, Mufio Vero G. Reviewing all available literature, combining both IV and oral steroid treatment, and recognizing variability in agents, dosing, and administration route, steroid therapy was successful in 76 out of 77 patients.

Manchada SA, Ravi P. Treatment of Sydenham chorea with corticosteroids. Brazil Language of fulltext: