Crossopteryx is a monotypic genus of flowering plants in the Rubiaceae family. The genus contains only one species, viz. Crossopteryx febrifuga, which is found . Crossopteryx febrifuga. Rubiaceae. (G. Don.) Benth. Crossopteryx febrifuga (Paul Latham). Crossopteryx febrifuga flower and fruit (Paul. Latham). Preparations of Crossopteryx febrifuga (Afzel.) Benth. (Rubiaceae) are widely used in Northern Nigeria in the therapeutic management of.
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Several areas of glandular destruction. This class of secondary compounds is able to protect the gastric mucosa against a variety of antiulcerogenic agents, particularly through scavenging properties on oxygen radicals by inhibition of nitric oxide Synthase activity Di Carlo et al.
Preparations of Crossopteryx febrifuga Afzel. Table 3 Results of Histopathology examinations. Anti-ulcer action of Panax japonicus rhizome. These rats were approved for use by the AFC committee after reviewing the protocol. The ulcer lesions were scored according to severity Larach and Malagelada, as follows: Histologic and microcirculatory changes in alcohol-induced gastric lesions in the rats: Piroxicam produced focal haemorrhagic gastric lesions and inflammation of the stomach mucosa in the rats.
West African Plants
One of such therapeutically useful medicinal plant is Crossopteryx febrifuga Benth, Family Rubiaceaea twisted tree with conspicuous tubular flowers, which is widely distributed throughout the Savannah region of Central, East and West Africa. Flavonoids have attracted the attention of many researchers because of their wide crossolteryx of biological activities Lewis and Hanson,including antiulcer properties La Casa et al.
The extract profoundly antagonized the Crossopgeryx induced ulceration in crissopteryx. In conclusion this study illustrated the safety of Crossopteryx febrifuga in gastrointestinal tract when used as an antiinflammatory analgesic agent that could be developed for management of painful inflammatory disorders.
Structural requirements crlssopteryx flavonoids for nitric oxide production inhibitory activity and mechanism of action. The method described by Salawu et al. The technical assistance of the Staff of Animal Facility center is highly appreciated. The rats were kept under the same conditions and observed for signs of toxicity which include but not limited to paw-licking, stretching, respiratory distress and mortality for the first critical 4h and thereafter daily for 7 days.
In the present study, the methanolic stem bark extract of Crossopteryx febrifuga was evaluated against ethanol- and piroxicam-induced ulceration in rats. Rubiaceae are widely used in Northern Nigeria in the therapeutic management of trypanosomiasis, malaria and painful inflammatory disorders.
Abstract Preparations of Crossopteryx febrifuga Afzel. Cyclooxygenase-2 inhibition increases gastric tone and delays gastric emptying in rats.
Effects of the extract on ethanol-induced gastric ulceration Ethanol produced haemorrhagic gastric lesions mainly in the glandular segment of the stomach mucosa. This article has been cited by other articles in PMC. Table 1 Effect of Crossopteryx febrifuga on ethanol-induced gastric ulceration in rats.
Oxygen free radicals and lipid peroxidation Takeuchi et al. Preparations of the tree is used traditionally for symptomatic relief of dry cough and for treatment of septic wounds, respiratory infections, fever, dysentery and pain. Six hours after piroxicam administration, the rats in all the groups were sacrificed under diethyl ether anesthesia.
The ulcer lesions were scored according to severity Larach and Malagelada, as follows:. The oral median lethal dose LD 50 of the methanolic extract was determined in rats orally using Lorke’s method with modifications. The cytoprotective effect of the extract may have been due to its ability to promote secretion of bicarbonate and production of mucus. Preparation of the plant extract The stem bark was cleaned, air-dried for seven 7 days and crushed into coarse powder using a pestle and mortar.
This observation further highlights the safety of the extract as an analgesic without gastrointestinal side effects associated with the traditional NSAIDs. The anti-ulcer effect of the extract may have been produced via enhanced prostaglandin synthesis, inhibition of leukotriene biosynthesis and decreased acid secretion. These rats were also observed for signs of toxicity and mortality for the first critical 4h and thereafter daily for 7 days.
Yesilada E, Takaishi Y.
Indian J Physiol Pharmacol. Ethanol produced haemorrhagic gastric lesions mainly in the glandular segment of the stomach mucosa. The differences between means of the treated and the control groups were compared using One way analysis of variance ANOVA followed by Dunnet’s post hoc test.
These results showed that the extract had no deleterious effects and crossopteryyx cytoprotective on the gastrointestinal tract git. The studies were carried out following the principles of good laboratory practice and animal handling National Institutes of Health Guide for the Care and use for Laboratory animals; Publication No.
The results obtained showed that the methanolic stem bark extract of Crossoptery febrifuga possesses significant antiulcer effect against ethanol- induced gastrointestinal ulceration in rats. This observed crossoptreyx effect of the methanolic stem bark extract of Crossopteryx febrifuga may have been produced by enhancing gastric mucosal defensive factors through increased gastric blood flow, increased mucus and bicarbonate secretion.
Gastro-Protective Effect of Crossopteryx Febrifuga in Wistar Rats
One hour after ethanol administration, the rats were sacrificed under diethyl ether anaesthesia.