Drug Dev Ind Pharm. Feb;25(2) Evaluation of Eudragit RS-PO and Ethocel matrices for the controlled release of lobenzarit disodium. matrix tablets by using Eudragit RSPO and natural gums like guar copal as rate The use of synthetic Eudragit RSPO and gum copal were unable to retard the. Although Eudragit RSPO has been widely used as sustained release material; to our knowledge the property of its combination with GC and Gd has not been.
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Similarly eudrragit Figure 3 ba higher EE was obtained with a decrease in ratio of a polymer to a drug and a maximum sonication time at a constant concentration of a surfactant. The dissolution test was performed in triplicate. The coefficient of determination 0.
Figure 4 shows 3D response surface plots showing the change of PDI corresponding to the change of independent variables. The reduced model for EE is presented in where, and are ratio of a polymer to a drug, concentration of a surfactant, and sonication time, respectively, and and are interaction effects between rsspo of a polymer to a drug and sonication time while is quadratic effect on EE.
A graphical representation of an optimized mean particle size is given in Figure 6: Effects of three independent parameters, namely, ratio of a polymer to a drugconcentration of surfactantand sonication time on average particles sizeparticle size eudraagit expressed as polydispersity index, PDIencapsulation efficiency EEand zeta potential were studied.
The solution was filtered through a 0. View at Google Scholar L. College of Pharmacy, Kamptee, Nagpur, India for providing necessary facilities to carry out this work. Click here to view all the property values for this datasheet as they were originally eurdagit into MatWeb.
Compression was carried out using 14 mm flat faced circular punches into tablets on an eight station rotary press tablet compression machine Eudragkt Minipress I Ahmadabad, India at a constant compression force.
Introduction Tenofovir is one of the first-line drugs used in the treatment of the human immunodeficiency virus HIV infected adults. El Baradi, and M.
Eudragit RSPO | Gum Copal | Gum Damar | Matrix Tablets | Release Kinetics
These parameters are often screened and optimized using highly automated statistical tools and rsoo of experiment. This means that the drug payload can be transported by diffusion.
Factors with values fspo are less than 0. For such drugs it becomes essential to include hydrophobic polymers in the matrix system [ 15 ]. It is a solid substance in form of white powder with a faint amine-like odour. Small mean particle size was obtained by low polymer to a drug having ratio of 1: Figure 5 b also shows that a decrease in ratio of a polymer resulted in an increased zeta potential with an increased sonication time. An closer to rdpo or 0.
This may be due to the increase erosion effect on the surface of large particle and particle agglomerates resulting in small particles [ 37 ]. The objective of present study was to develop an optimized polymeric nanoparticle system for the antiretroviral drug tenofovir. Granulation was done manually with a solution of isopropyl alcohol. An angle of repose of less than 30 degrees indicates good flow properties. They were selected at their low, medium, and eudratit levels with replicated centre points as shown in Table 1.
The influence of tspo polymer concentration in the tablets was also investigated. The optimized formulation was characterized for in vitro drug release and structural characterization. The quadratic model of zeta potential is shown in where, and represent ratio of a polymer to a drug, concentration of a surfactant, and sonication time, respectively, euudragit and are interaction effects between ratio of a polymer to a drug and sonication time and concentration of a surfactant and sonication time while are quadratic effect.
The FTIR showed some noncovalent interactions between the drug and polymer but a eudragitt release was observed in vitro for up to 80 hours. The coefficient of determination of the model for mean particle size was 0. However, the use of hydrophilic matrix alone for extending drug release for highly water soluble drugs is restricted due to rapid diffusion of the dissolved drug through the hydrophilic gel network.
Journal of Nanomaterials
Figure 6 in vitro cumulative release of metformin. Property Data This page displays only the text of a material data sheet. The change in spectra of the drug in the presence of polymer was investigated which indicates the physical interaction of drug molecule with the polymer.