Materials and Methods: Emulgel formulations of diclofenac potassium were prepared using different . subjected to various evaluation parameters such as drug. Emulgels have been extensively covered as a promising drug delivery system for the administration of lipophilic drugs. This work was. Formulation and Evaluation of Luliconazole Emulgel for. Topical Drug Delivery. Dhobale Shankar,* Shelke Gajanan, Jadhav Suresh, Gaikwad.

Author: Kazranris Faekora
Country: New Zealand
Language: English (Spanish)
Genre: Spiritual
Published (Last): 25 October 2006
Pages: 139
PDF File Size: 8.48 Mb
ePub File Size: 7.12 Mb
ISBN: 211-7-93116-283-1
Downloads: 30607
Price: Free* [*Free Regsitration Required]
Uploader: Yozshurn

The study also highlights preclinical analysis, that aceclofenac and diclofenac show equal efficacy when used topically.

Clindamycin is a lincosamide antibiotic. November 12, Journal article Open Access. The anti-inflammatory activity was evalation more in voltaren emulgel as compared to aceclofenac emulgel. Microemulsions are thermodynamically stable and enhance drug permeation and release.

Most read articles by the same author s S.

Hence, the micro emulsion was considered optimum in terms of these pharmaceutical characteristics. However, a prominent drawback in formulating gels annd difficulty in delivery of hydrophobic drug. Previous studies have attempted formulation of aceclofenac in emulgels and gels, however, the data regarding formulation of microemulsion-based emulgel of aceclofenac and head-to-head comparison of anti-inflammatory activity with the most popular marketed emulgel is not reported in the literature 15 – Formulation and evaluation of oxiconazole emulgel for topical drug delivery Author: However, the implications of this phenomenon, when the drugs are administered topically remain a question to be addressed in future studies.

Aceclofenac is a non-steroidal anti-inflammatory drug NSAID glycolic ester of diclofenac, used for certain joint disorders. Undesirable skin formluation, i. Dr Ashok Kumar Verma. Moreover, the reduction in inflammation was comparable to that of qnd most consumer preferred anti-inflammatory emulgel brand of diclofenac.



Isopropyl myristate showed best solubility amongst all the oils, polysorbate 80 showed two times better solubility than other surfactants and Ethanol showed the 5 times better solubility amongst co-surfactants. The microemulsion which had highest amount of drug solubility and formulayion uptake in the pseudo ternary phase diagram was chosen for trials on microemulsion. Thus, the microemulsion based aceclofenac emulgel showed promising results as an effective anti-inflammatory topical drug delivery system, in this preliminary investigation.

Samples were analyzed for drug content by UV-Vis spectrophotometer after appropriate dilutions.

Formulation and evaluation of Cyclosporin A emulgel for ocular delivery.

So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies. The findings of the study may yield further avenues for researchers as well as formulation scientists ot design evaulation studies on aceclofenac emulgel formulations, using the optimized microemulsion techniques.

Hence, the formulation strategy for aceclofenac and thereby, an efficient drug delivery led to an effective anti-inflammatory activity. Herein, no further evaluation and animal studies were done to assess the implications of the formulation in vivo.

Hence, we addressed the issues of previously published studies, presenting a novel research.

Voltaren emulgel produced maximum inhibition of The late phase of the inflammatory response has been shown to be due to potentiating effect of bradykinin on mediator release and prostaglandins, producing edema after qnd of the leukocytes as studied by Necas and Bartosikova 19 and Siqueira et al.

However, these differences were not statistically significant.

The aim of present study was to develop an emulgel formulation of clindamycin phosphate using Carbopol or HPMC as a gelling agent. Evaluation of microemulsion 4 – 7 Appearance and pH: Aceclofenac is a non-steroidal anti-inflammatory drug used for pain relief and inflammation in certain joint disorders.


The activity produced emulfel the formulated emulgel was at par with the most marketed emulgel formulation. Formulation, development and evaluation of emulgel: Microemulsion-based media as novel drug delivery systems.


Clindamycin emulgel, Formulation, Evaluation. Particle size and Zeta potential analysis: The highest drug release was observed with T4, where the drug release showed Hence, developing formulation strategies for aceclofenac is particularly imperative 12. Most remarkable finding was that the anti-inflammatory activity exhibited by aceclofenac microemulsion-based emulgel.

The inflammation in the ear of each rat was noted using Vernier caliper at 1st, 2nd, 3rd and 4th h of treatment. A novel approach for enhancing topical delivery of aceclofenac. Additionally, microemulsions have improved stability 12 – February 21, ; Accepted: The oxiconazole used in treatment of various fungal infections such as cutaneous and subcutaneous diseases like acne and psoriasis. If you encountered difficulties to submission of new manuscripts then you feel free to evauation all the manuscripts to the Editor by e-mail as “attachment” to the electronic addresses: In this study, polymer-based emulgel formulation of aceclofenac with a microemulsion base was developed and assessed for its anti-inflammatory activity.