DAÑO AXONAL DIFUSO SECUNDARIO A TRAUMATISMO CRANEOENCEFÁLICO Neurología del paciente en situación critica ( Neurocríticos).

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The Journal of Neuroscience. Unfortunately little can be done for patients with diffuse axonal injury other than trying to minimise secondary damage caused by cerebral edema, hypoxia, etc.

In the majority of cases, these forces result in damage to the cells and result in edema. Actual complete tearing of the axons is only seen in severe cases. Mitochondriadendritesand parts of the cytoskeleton damaged in the injury have a limited ability to heal and regenerate, a process which occurs over 2 or more weeks.

Diffuse axonal injury | Radiology Reference Article |

The patients at risk of diffuse axonal injury belong to the same cohort as those who suffer traumatic brain injury and as such young men are very much over-represented. The appearance depends on whether or not the lesions are overtly hemorrhagic. Neuroimaging Clinics of North America. MRI, especially SWI or GRE sequences, exquisitely sensitive to paramagnetic blood products may demonstrate small regions of susceptibility artefact at the grey-white matter junction, in the corpus callosum or the brain stem.


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Diffuse axonal injury – Wikipedia

Black eye Eye injury Corneal abrasion. Articles Cases Courses Quiz. Axons are normally elastic, but when rapidly stretched they become brittle, and the axonal cytoskeleton can be broken. Susceptibility weighted image SWI of diffuse axonal injury in trauma at 1.

MRI is the modality of choice for assessing suspected diffuse axonal injury even in patients with entirely normal CT of the brain In other projects Wikimedia Commons. Howard University College of Medicine. Traumatically induced axonal damage: Support Radiopaedia and see fewer ads.

Diffuse injury has more microscopic injury than macroscopic injury and is difficult to detect didusa CT and MRI, but its presence can be inferred when small bleeds are visible in the corpus callosum or the cerebral cortex.

Journal of Neurology, Neurosurgery, and Psychiatry. Axoplasmic transport and neuronal responses to injury Archived at the Wayback Machine.

The amount of axonal injury in the brainstem is predictive of long-term vegetative state, whereas supratentorial injury can result in focal neurological or neuropsychiatric deficits 1.

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Non-contrast CT of the brain is routine in patients presenting with head injuries. Case 7 Case 7. In Grade I, widespread axonal damage is present but no focal abnormalities are seen. difussa


Though the processes involved in secondary brain injury are still poorly understood, it is now accepted that stretching of axons during injury causes physical disruption to and proteolytic degradation of the cytoskeleton. Diffuse axonal injury Susceptibility weighted image SWI of diffuse axonal injury in trauma at 1.

When lesions are hemorrhagic, and especially when they are large, then CT is quite sensitive. Since axonal damage in DAI is largely a result of secondary biochemical cascades lesio, it has a delayed onset, so a person with DAI who initially appears well may deteriorate later.

Diffuse axonal injury

This is to be expected as edema is faster to resolve than hemorrhage. The idea of DAI first came about as a result of studies by Sabina Strich on lesions of the white matter of individuals who had suffered head trauma years before. About Blog Go ad-free. You can also scroll through stacks with your mouse wheel or the keyboard arrow keys. Thank you for updating your details. Traumatic axonal injury induces calcium influx modulated by tetrodotoxin-sensitive sodium channels.