Lupus miliaris disseminatus faciei (LMDF) is a granulomatous eruption characterized by monomorphic, reddish-brown papules and nodules predominantly. A biopsy specimen revealed epithelioid cell granulomas with central necrosis, consistent with a diagnosis of lupus miliaris disseminatus faciei (Figure 2). Lupus miliaris disseminatus faciei (LMDF) first described in is an uncommon dermatosis of unknown etiology with characteristic.

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Various treatments have been tried with tetracyclines, isotretinoin, dapsone, prednisolone, clofazimine, isoniazid and corticosteroids, with variable results.

Muller J Med Sci Res ;8: Received Mar 10; Accepted Apr The histopathological hallmark of LMDF is a dermal epithelioid cell granuloma with central necrosis, but the histological pattern can vary according to the stage diseminatus the lesion. Extrafacial involvement in LMDF has been faciiei reported in the literature. Is it a variant of lupus miliaris disseminatus faciei? Register for email alerts with links to free full-text articles Access PDFs of free articles Manage your interests Save searches and receive search alerts.

Is ‘lupus miliaris disseminatus faciei’ still an acceptable diagnosis in the third millennium?

Oral minocycline therapy mg twice a day was initiated but was discontinued shortly thereafter because of drug-induced urticaria. The exact etiopathogenesis of LMDF remains unknown. Get free access to newly published articles Create a personal account or sign in to: Granulomas were composed of epithelioid cells, plenty of Langhan’s and foreign body giant cells surrounded by a lymphocytic cuff [ Figure 2 ].

A clinical and histologic study of granulomatous rosacea. Multinucleated giant disseminatu were seen in eight cases Figure 3. Clinicians, local and regional societies, residents, and fellows are invited to submit cases of challenges in management and therapeutics to this section.


We suggest that the presence of epitheloid granulomas with central caseation in these cases warrants consideration that these entities may actually represent part of the spectrum of disease of LMDF.

Lupus miliaris disseminatus faciei

The case series included 6 men and 4 women from 6 to 79 years of age mean, It appears to be a granulomatous reaction most often related to destruction of the pilosebaceous unit and the resultant antigen exposure, but it remains clinically distinct from granulomatous rosacea and periorificial dermatitis, and in fact the etiology may be multifactorial.

Therapy is disdeminatus with variable efficacy and several therapeutic modalities, e. Lever’s Histopathology of the Skin. Fragmented skin biopsy showing mild focal acanthosis with focal follicular plugging. Rocas D, Kanitakis J. A year-old male presented with 4 months history of asymptomatic, reddish-raised lesions over the face, earlobes, and the neck. Lymphocytes were seen in eight cases Figure ; the lymphocytes formed an outer layer surrounding the granuloma in four cases Figure 3.

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Lupus miliaris disseminatus faciei is a rare dermatologic disease that is characterized clinically by milairis presence of discrete, red-brown, dome-shaped papules on the face. Further information is needed to clarify the diagnosis, etiology, and pathogenesis of this disease, but an unusual host response to folliculitis or follicular injury likely plays a role in most cases.

The granulomas are comprised of histiocytes macrophagesa variable number of multinucleated giant cells of the Langhans or foreign body type, occasional neutrophils, and a peripheral rim of lymphocytes [ 129 ]. J Am Acad Dermatol. In seven of the cases, a perifollicular distribution of the granulomas was noted Figure 2.

A chronic infiltrate often accompanies the granulomas. He works in biscuit wrapper manufacturing unit; but there is no history of contact with any chemical or fumes. There are a number of possible mechanisms by which the nm diode laser can improve lupus miliaris disseminatus faciei.


A Review of Lupus Miliaris Disseminatus Faciei-Like Histopathologic Changes in 10 Cases

Lupus miliaris disseminatus faciei — The DNA of Mycobacterium tuberculosis is not detectable in active lesions by polymerase chain reaction. Therefore, only the fully developed lesions subclassified as lypus epithelioid granuloma with central caseation necrosis are represented in our sample.

Facidi only treatment-related adverse effects were treatment-site erythema and edema that lasted 1 to 2 days. LMDF has been considered to be a form of granulomatous rosacea, supported by the frequent close association with pilosebaceous units [ 117 ].

No recurrence was noted over a month observation period. The early lesions are characterized by superficial perivascular and periappendageal infiltrates composed primarily of lymphocytes with a few histiocytes and neutrophils.

Lupus miliaris disseminatus faciei pathology | DermNet NZ

Caseation necrosis is variable and usually seen in fully developed LMDF disseminatud. A variety of treatments including tetracyclines, dapsone, isotretinoin, tranilast, oral corticosteroids, and combination therapies have shown variable efficacy in LMDF [ 151011 ].

If the diagnostic criteria were expanded to include the histologic presentation of early and late lesions as well as the other sub-classifications of fully developed lesions, the sample size would almost certainly have increased. Lupus miliaris disseminatus faciei is a rare inflammatory dermatosis of unknown etiology that primarily affects young adults.

Significant clinical improvements in skin lesions were noted 4 weeks after the first treatment. Author information Copyright and License information Disclaimer.