Bisphenol A (BPA)—an endocrine disruptor xenoestrogen—is widely spread in the environment. Lycopene (LYC) is an antioxidant. Background: The exact role of lycopene has not been studied in the past for its hepatoprotective effects. Hence it was decided to explore its anti-oxidant and. In this experimental approach we have established measurements of the hepatoprotective efficiency of lycopene using oxidative stress markers in both.

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Non-alcoholic fatty liver disease NAFLD is one of the causes of fatty liver, occurring when fat is deposited steatosis in the liver due to causes other than excessive alcohol use.

Rao AV, Agarwal S.

Hepatoprotective Effect of Olive and Argan Oils Supplemented with Tomato Lycopene in Wistar Rats

Drug induced liver disease. The sections were then incubated with 0. Grade B Very good: A link between the elevated homocysteine level and oxidative stress has been demonstrated. It has been reported that BPA can cause hepatic hrpatoprotective 8 ], renal [ 9 ], cerebral [ 10 ], and other organs damage by producing reactive oxygen species ROS [ 11 ]. J Inflamm Lond ; Effect of lycopene on lycopeme density lipoprotein-cholesterol, high density lipoprotein-cholesterol and free fatty acid levels in liver tissue.

Measurement of antioxidant and antioxidant enzyme activity SOD and GSH activity were determined by commercial kit from Jiancheng Biological Engineering Institute following the protocol provided by the manufacturer.

These results were similar to those obtained by Eid et al. On the other hand, some reports in the literatures were inconsistent to our findings, where Rubin et al. Rats supplemented with LYC only did not differ from the control group Table 2.

View at Google Scholar D. Association of lycppene fatty liver disease with insulin resistance. Hepatic cytochrome P 2E1 is increased in patients with nonalcoholic steatohepatitis. Non alcoholic fatty liver: Mortensen A, Skibsted LH. Journal of Taibah University for Science.


Current results were parallel to the previous results of Abdel Samie et al. In addition, Ly was shown to protect human LDL against photosensitized oxidative damage[ 32 ].

Oxidative Medicine and Cellular Longevity

The role of the antioxidants lycopene and vitamin E in the prevention of halothane-induced hepatotoxicity. Schuppan D, Schattenberg JM. Relative stability of carotenoid radical cations and homologue tocopheroxyl radicals. Possible hepatoprotectivee and neuroinflammation modulation. Liver Comet Assay Single-cell suspensions were prepared from frozen livers according to the method described by Smith et al.

Thus, promoting blood circulation to remove meridian obstruction, reducing phlegm, removing dampness and liver-kidney-tonifying are an effective approach to treatment hepatoprotecttive NAFLD. Hence, developing and exploring a novel agent to delay or reverse the pathogenesis progression in NAFLD are very important objectives.

Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat

Mohamed4 and Aaser M. Lycopene LYC is a natural antioxidant and free radical scavenger lipophilic carotenoid present in food especially tomatoes giving it the red color [ 17 ]. Table 1 Effect of lycopene on serum liver function markers and blood lipid levels.

Journal List World J Gastroenterol v. Serum and tissue lycopene and biomarkers of oxidation in prostate cancer patients: Hepatoprotective and antioxidant effects of Cuscuta chinensis against acetaminophen-induced hepatotoxicity in rats. Antioxidants and Oxidative Stress Measurements 2. Antioxidants are present naturally in the living cells as superoxide dismutase, catalase, glutathione reductase, and glutathione oxidase [ 13 ] or are available in food such as carotenoids, polyphenols, and vitamins C and E [ 14 ].

This is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A Grade B Very good: Virgin olive oil VOO and argan oil AO contain a wide variety of phytochemicals which are considered as a functional foods. Human fatty liver disease: Ly exhibits a range of distinct and unique biological properties owing to its acyclic structure, hydrophobicity and large array of conjugated double bonds.

The occurrence of abnormalities in lipid profile is considered the starting station for induction of oxidative stress and lipid peroxidation [ 58 ] that were observed in the current study. Due to the wide spreading of the usage of BPA in manufacture, both animals and human are daily exposed to BPA hazardous effects [ 6 ]. Pakistan Journal of Nutrition, The lycopen enrichment VOO and AO significantly improved the beneficial effects derived from hepatoprotectige consumption of both oils on serum liver enzymes and protect the liver tissue by enhancing the hepatic lycopene concentration, induced hepatoprotective effect by ameliorating the capacity antioxidant and function parameters of the liver tissue in wistar rats.

BPA has the capability to disrupt the lipid metabolism [ 56 ] and trigger lipid accumulation through differentiation of 3T3-L1 fibroblasts into adipocytes [ 57 ].

High-density lipoprotein cholesterol HDL-c and low-density lipoprotein cholesterol LDL-c were determined as described by Bachorik [ 29 ]. Body and Liver Nepatoprotective Rats were weighed at the beginning hepatoprotetive the experiment and then weighed at the end of the experiment. The imbalance between the free radical production and elimination leads to oxidative stress which can cause hepatic damage [ 3 ].